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Ketof is used for Allergic or seasonal conjunctivitis, Itching of the eye, Itching of the eyes and other conditions. Ketof may also be used for purposes not listed in this medication guide.It contains Ketotifen Fumarate as an active ingredient.Ketof works by inhibiting the release of allergy-causing chemicals, histamines in the body by mast cells.
Increased heart rate, shallow breathing, hives, nausea, high blood pressure, headache, rashes and itching.
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Ketotifen exhibits anti-allergic qualities and was used in prophylactic asthma similarly with sodium cromoglycate. It has antihistamine effects, too. Ketotifen has marked anti-anaphylactic properties and prevents asthma attacks. Ketotifen has a sustained effect on histamine reactions and can clearly be dissociated from its anti-anaphylactic features.
Experimental testing in asthmatic subjects has shown that Ketotifen is as effective orally as the selective mast cell stabilizers delivered by inhalation. These experiments did not work for antihistamines. In long-term clinical trials, the efficacy of Ketotifen was tested.
The number, severity and duration of asthma attacks have been decreased and patients in some cases have been entirely released from attacks. It was also necessary to gradually reduce corticosteroids. Ketotifen will take several weeks to completely develop its prophylactic activity.
Ketotifen is a potent anti-allergic agent that has a strong and persistent receptor blocking feature of non competitive histamine (H1). It blocks the release from the cells responsible for allergy reactions of type-(I) by mediators (e.g. histamine, leukotrienes, and prostaglandin). Ketotifen stabilizes mast cells, lowers chemotaxis, stimulates eosinophils degranulation. It also stabilizes and prevents PAF (platelet activation factor) mast cells & basophils and acts to deter asthmatic attacks
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